A study confirms that in Nigeria, as elsewhere, women infected with the human papillomavirus (HPV) types 16 and 18 are at higher risk of developing invasive cervical cancer than those infected with other high-risk HPV types. Current HPV16/18 vaccines have enormous potential to reduce cervical cancer in Nigeria, the study concluded.
In the general population, 26.3 percent of women were HPV-positive, among whom the prevalence of HPV35 and HPV16 were equally frequent (12 percent). Among those with cervical cancer, however, HPV16 predominated strongly (67.6 percent of HPV-positive cases), with the next most common types being 18 (10.3 percent), 35, 45 and 56 (each 5.9 percent).
Comparing among HPV-positive women only, HPV16 and HPV18 were over-represented in cervical cancer cases versus the general population. Other high-risk HPV types, as well as low-risk and multiple HPV infections were less common in HPV-positive women with cervical cancer than from the general population.
1. Okolo C, Franceschi S, Adewole I, et al. Human papillomavirus infection in women with and without cervical cancer in Ibadan, Nigeria. Infectious Agents and Cancer 2010; 5: 24. (open access)